Terapia con células madre mesenquimales en la dermatitis atópica en animales pequeños: evidencia clínica, inmunomodulación y remodelación cutânea
DOI:
https://doi.org/10.66104/2vzz3z66Palabras clave:
Wearable sensors; Injectable sensors; Ingestible sensors; Implantable sensors; Integrated sensors.Resumen
El Internet de los Cuerpos (IoB) representa una frontera tecnológica emergente que extiende la conectividad digital directamente al ámbito humano, integrando el cuerpo en las redes de información. Este artículo analiza el IoB y sus diversas categorías de dispositivos, que incluyen dispositivos portátiles (wearables), inyectables, ingeribles, implantables e integrados. Cada tipo de dispositivo desempeña un papel único en la recopilación y transmisión de datos fisiológicos y conductuales, desde monitores de salud externos hasta interfaces neuronales avanzadas. El objetivo de este trabajo es analizar el potencial transformador de la IoB, especialmente en el ámbito de la salud y el bienestar, donde la monitorización continua y la intervención personalizada pueden revolucionar la prevención, el diagnóstico y el tratamiento de enfermedades. Analizamos cómo los dispositivos wearables pueden optimizar el rendimiento y la seguridad, mientras que los inyectables, ingeribles e implantables ofrecen nuevos enfoques para el diagnóstico interno y las terapias. Sin embargo, la proliferación del IoB plantea retos importantes. La investigación aborda las complejas cuestiones relacionadas con la privacidad de los datos, dada la naturaleza sensible de la información biométrica recopilada, y las preocupaciones imperativas en materia de ciberseguridad, que pueden tener implicaciones críticas para la integridad y la vida de las personas. Además, se examinan las consideraciones éticas y de gobernanza, incluyendo el consentimiento, la autonomía y el riesgo de sesgo algorítmico. Concluimos que, aunque el IoB promete avances sin precedentes, su desarrollo e implementación exigen un marco regulatorio sólido y un enfoque multidisciplinar que equilibre la innovación con la protección individual y social. La colaboración entre las partes interesadas es esencial para garantizar un futuro en el que el IoB beneficie a la humanidad de forma segura y ética.
Descargas
Referencias
CELIK, A.; ELTAWIL, A. M. The internet of bodies: The human body as an efficient and secure wireless channel. IEEE Internet of Things Magazine, v. 5, n. 2, p. 94-100, 2022. DOI: 10.1109/IOTM.001.2200021
MATWYSHYN, A. M. The Internet of Bodies. SSRN Electronic Journal, 2019. DOI: 10.2139/ssrn.3452891
EL-KHOURY, M.; ARIKAN, C. L. From the internet of things toward the internet of bodies: Ethical and legal considerations. Strategic Change, v. 30, n. 3, p. 249-260, 2021. DOI: 10.1002/jsc.2411
SANTOS, E.J.C.; MAZZEO, A. Cyberbiosecurity in medicine: protecting data and patients in the digital age. Rev Med (São Paulo). 104(6):e-236087, 2025. DOI: http://dx.doi.org/10.11606/issn.1679-9836.v104i6e-236087
AMATO, C. Internet of bodies: Digital content directive, and beyond. JIPITEC, v. 12, p. 117, 2021. Link
XIAO, L. et al. The Internet of Bodies: Opportunities, Risks, and Governance. RAND Corporation, 2020. DOI: 10.7249/RR3226
MARTINELLI, Maria Lúcia. Pesquisa qualitativa: um caminho para a intervenção profissional. São Paulo: Editora Brasiliense, 1999
MARCONI, M. A; LAKATOS, E. M. Fundamentos da Metodologia Científica. São Paulo: Editora Atlas, 2003.
BODDINGTON G. The Internet of Bodies-alive, connected and collective: the virtual physical future of our bodies and our senses. AI Soc., 1-17, 2021. DOI: http://dx.doi.org/10.1007/s00146-020-01137-1.
MAZZEO, A; SANTOS, E.J.C. Integration of biomedical devices and the internet of bodies revolution. Research, Society and Development, [S. l.], v. 14, n. 5, p. e11814548921, 2025. DOI: 10.33448/rsd-v14i5.48921.
BIBRI, S. E. The Metaverse as a Virtual Model of Platform Urbanism: Its Converging AIoT, XReality, Neurotech, and Nanobiotech and Their Applications, Challenges, and Risks. Smart Cities, v. 6, n. 3, p. 1330-1384, 2023. DOI: 10.3390/smartcities6030065
LIU, H.; GUO, D.; CANGELOSI, A. Embodied Intelligence: A Synergy of Morphology, Action, Perception, and Brain. ACM Computing Surveys, 2025. DOI: 10.1145/3717059
CHATTERJEE, B. et al. Bioelectronic Sensor Nodes for the Internet of Bodies. Annual Review of Biomedical Engineering, v. 25, p. 183-209, 2023. DOI: 10.1146/annurev-bioeng-110220-112448
GRAVINA, R., & FORTINO, G. Wearable Body Sensor Networks: State-of-the-Art and Research Directions. IEEE Sensors Journal, 21(11), 12511-12522, 2020. https://doi.org/10.1109/JSEN.2020.3044447
LIU, J., & LIU, H. Research on Flexible Sensors for Wearable Devices: A Review. Nanomaterials (Basel, Switzerland), 15(7), 520, 2025. https://doi.org/10.3390/nano15070520
SARAVANAKUMAR, R., BEDI, P., JAYADEVAPPA, D., & TUNGA, S. IoB: Sensors for Wearable Monitoring and Enhancing Health Care Systems. IEEE Instrumentation & Measurement Magazine, 25(3), 63-70, 2022. https://doi.org/10.1109/MIM.2022.9759352
KHAN, S., & ALAM, M. Wearable Internet of Things for personalized healthcare: Study of trends and latent research. Health informatics: a computational perspective in healthcare, 43-60, 2021. DOI: 10.1007/978-981-15-9735-0_3
GHIWAA, T.; KHAN, I.; WHITE M. & BELOFF, N. (2024). "IoB-TMAF: Internet of Body-based Telemedicine Adoption Framework," 2024 19th Conference on Computer Science and Intelligence Systems (FedCSIS), Belgrade, Serbia, 2024, pp. 343-353, doi: 10.15439/2024F4805.
KIOURTI, A.; NIKITA, K. S. A Review of In-Body Biotelemetry Devices: Implantables, Ingestibles, and Injectables. IEEE Transactions on Biomedical Engineering, v. 64, n. 7, p. 1422-1430, 2017. DOI: 10.1109/TBME.2017.2651433
JUNG, Y. H. et al. Injectable Biomedical Devices for Sensing and Stimulating Internal Body Organs. Advanced Materials, v. 32, n. 16, p. 1907478, 2020. DOI: 10.1002/adma.201907478
STEIGER, C., ABRAMSON, A., NADEAU, P., & TRAVERSO, G. Ingestible electronics for diagnostics and therapy. Nature Reviews Materials, 4(2), 83-99, 2019. DOI: 10.1038/s41578-018-0070-3
ABDIGAZY, A., ARFAN, M., LAZZI, G., SIDERIS, C., & TRAVERSO, G. End-to-end design of ingestible electronics. Nature Electronics, 7, 1-15, 2024. DOI: 10.1038/s41928-024-01122-2
DATTA, S., et al. IoB: The Vision of the Internet of Bodies. IEEE 63rd International Midwest Symposium on Circuits and Systems (MWSCAS), 2020. DOI: 10.1109/MWSCAS48756.2020.9184837
HAFEZI, H., et al. An ingestible sensor for measuring medication adherence. IEEE Transactions on Biomedical Engineering, 62(1), 99-109, 2015. DOI: 10.1109/TBME.2014.2346459
ALIPOUR, A., et al. Ingestible Sensors and Medication Adherence: Focus on Use in Serious Mental Illness. Pharmacy, 8(2), 103, 2020. DOI: 10.3390/pharmacy8020103
MULES TC, CAMBERIS M, LAVENDER B, PAYNE K, YUMNAM B, VACCA F, NOBLE SL, TANG JS, TE KAWA T, WHELLER G, LE GROS G, INNS S. Exploratory study characterizing gastrointestinal physiological changes during controlled human hookworm infection. Am J Physiol Gastrointest Liver Physiol. 330(2):G206-G213, 2026. doi: 10.1152/ajpgi.00300.2025.
LITVINOVA O, KLAGER E, YEUNG AWK, TZVETKOV NT, KIMBERGER O, KLETECKA-PULKER M, WILLSCHKE H, ATANASOV AG. Bibliometric analysis and evidence of clinical efficacy and safety of digital pills. Front Pharmacol., 14:1023250, 2023. doi: 10.3389/fphar.2023.1023250.
DATTA, S., et al. Intelligent ingestibles: Future of internet of body. IEEE 63rd International Midwest Symposium on Circuits and Systems (MWSCAS), 2020. DOI: 10.1109/MWSCAS48756.2020.9184837
LYU, X., HU, Y., et al. Hydrogel Bioelectronics for Health Monitoring. Biosensors, 13(8), 815, 2023. DOI: 10.3390/bios13080815
ESTRELA, V. V., et al. In-body devices and sensors communication–how implantables, ingestibles, and injectables interact with the internet. Intelligent Healthcare, 243-268, 2023. DOI: 10.1201/9781003196822-14
NICHOLS SP, BALACONIS MK, GANT RM, AU-YEUNG KY, WISNIEWSKI NA. Long-Term In Vivo Oxygen Sensors for Peripheral Artery Disease Monitoring. Adv Exp Med Biol, 1072:351-356, 2018. doi: 10.1007/978-3-319-91287-5_56.
LIU J, FANG X, ZHANG Z, LIU Z, LIU J, SUN K, YUAN Z, YU J, CHIU DT, WU C. Long-Term In Vivo Glucose Monitoring by Polymer-Dot Transducer in an Injectable Hydrogel Implant. Anal Chem., 94(4):2195-2203, 2022. doi: 10.1021/acs.analchem.1c04730.
YOGEV, D., GOLDBERG, T., ARAMI, A., TEJMAN-YARDEN, S., WINKLER, T. E., & MAOZ, B. M. Current state of the art and future directions for implantable sensors in medical technology: Clinical needs and engineering challenges. APL Bioengineering, 7(3), 031506, 2023. DOI: 10.1063/5.0152290
LEE, J., HAN, S. Y., & KWON, Y. W. Technological advances and medical applications of implantable electronic devices: From the heart, brain, and skin to gastrointestinal organs. Biosensors, 15(8), 543, 2025. DOI: 10.3390/bios15080543
BASSANI P.S. The internet of bodies, emergent realities and the emergence of digital architectures of interaction. Revista Contrapontos, 22(1): 175-187, 2021. DOI: 10.14210/contrapontos.v22n1.p175-187
OBEID, P. J., YAMMINE, P., EL-NAKAT, H., KASSAB, R., TANNOUS, T., NASR, Z., MAARAWI, T., DAHDAH, N., EL SAFADI, A., MANSOUR, A., & CHMAYSSEM, A. Organ-On-A-Chip Devices: Technology Progress and Challenges. Chembiochem: a European journal of chemical biology, 25(23), e202400580, 2024. DOI: https://doi.org/10.1002/cbic.202400580
XIN Y, SUN B, KONG Y, ZHAO B, CHEN J, SHEN K, ZHANG Y. Advances in integrated power supplies for self-powered bioelectronic devices. Nanoscale. 17(5):2423-2437, 2025. doi: 10.1039/d4nr04645e.
SANTOS, E.J.C., MAZZEO, A. Ciberbiosegurança em ambientes biointeligentes: Integração de inteligência artificial, biologia sintética e automação em setores vitais. Research, Society and Development, v. 14, n. 6, e5714648937, 2025. DOI: http://dx.doi.org/10.33448/rsd-v14i6.48937
KALANTAR-ZADEH, K., et al. Ingestible Sensors. ACS Sensors, 2(4), 468-483, 2017. DOI: 10.1021/acssensors.7b00045
HASSIJA V, CHAMOLA V, BAJPA B C, NAREN, ZEADALLY S. Security issues in implantable medical devices: Fact or fiction? Sustainable Cities and Society, v. 66, p. 102552, 2021. DOI: 10.1016/j.scs.2020.102552.
AL-KAHTANI, M. S., et al. Application of Internet of Things and Sensors in Healthcare. Sensors, 22(15), 5738, 2022. DOI: 10.3390/s22155738
ATES, H. C., YETISEN, A. K., HENG, C. H., TAGHINEJAD, H. End-to-end design of wearable sensors. Nature Reviews Materials, 7(8), 613-631, 2022. DOI: 10.1038/s41578-022-00460-x
GU, Y., LI, Y., WANG, Z.Z, HANG, Y. Injectable Biomedical Devices for Sensing and Stimulating Internal Body Organs. Advanced Materials, 32(9), 1907478, 2020. DOI: 10.1002/adma.201907478
LU, T., JI, S., JIN, W., YANG, Q., LUO, Q., & REN, T. L. Biocompatible and Long-Term Monitoring Strategies of Wearable, Ingestible and Implantable Biosensors: Reform the Next Generation Healthcare. Sensors, 23(6), 2991, 2023. DOI: 10.3390/s23062991
SCHEIDT, D. T., MORELI, M. L., MATERÓN, E. M. Exploring Novel Healthcare Monitoring Modalities: Wearable, Ingestible, and Implantable Biosensors. In Nano-bioelectronics for Healthcare (pp. 101-125). Springer, 2025. DOI: 10.1007/978-981-95-2117-3_5
MUKHERJEE S, SULEMAN S, PILLOTON R, NARANG J, RANI K. State of the Art in Smart Portable, Wearable, Ingestible and Implantable Devices for Health Status Monitoring and Disease Management. Sensors (Basel). 22(11):4228, 2022. doi: 10.3390/s22114228.
ABHINAV V, BASU P, VERMA SS, VERMA J, DAS A, KUMARI S, YADAV PR, KUMAR V. Advancements in Wearable and Implantable BioMEMS Devices: Transforming Healthcare Through Technology. Micromachines (Basel). 16(5):522, 2025. doi: 10.3390/mi16050522.
KHALIFA A, LEE S, MOLNAR AC, CASH S. Injectable wireless microdevices: challenges and opportunities. Bioelectron Med. 7(1):19, 2021. doi: 10.1186/s42234-021-00080-w.
Ghanim R, Kaushik A, Park J, Abramson A. Communication protocols integrating wearables, ingestibles, and implantables for closed-loop therapies. Device, v. 1, n. 3, p. 100144, 2023. DOI: 10.1016/j.device.2023.100144
PHATAK AA, WIELAND FG, VEMPALA K, VOLKMAR F, MEMMERT D. Artificial Intelligence Based Body Sensor Network Framework-Narrative Review: Proposing an End-to-End Framework using Wearable Sensors, Real-Time Location Systems and Artificial Intelligence/Machine Learning Algorithms for Data Collection, Data Mining and Knowledge Discovery in Sports and Healthcare. Sports Medicine Open. 2021 Oct 30;7(1):79. DOI: 10.1186/s40798-021-00372-0.
MARTÍNEZ RUIZ I, CANO SUÑÉN E, MARCO MARCO Á, FERNÁNDEZ CUELLO Á. IoB Internet of Things (IoT) for Smart Built Environment (SBE): Understanding the Complexity and Contributing to Energy Efficiency; A Case Study in Mediterranean Climates. Applied Sciences. 15(4):1724, 2025. DOI: 10.3390/app15041724
MOUSTATI I, GHERABI N, SAADI M. Building an IoB ecosystem for influencing energy consumption in smart cities. Data and Metadata, 3:441, 2024. DOI: 10.56294/dm2024.441
ZHOU J, PARK S, DONG S, TANG X, WEI X. Artificial intelligence-driven transformative applications in disease diagnosis technology. Med Rev (2021). 5(5):353-377. 2025. doi: 10.1515/mr-2024-0097.
CHEN L, XIA C, ZHAO Z, FU H, CHEN Y. AI-Driven Sensing Technology. Sensors (Basel). 24(10):2958, 2024. DOI: 10.3390/s24102958.
MARINESCU MR, IONESCU ON, PACHIU CI, DINESCU MA, MULLER R, ȘUCaHEA MP. Next-Gen Healthcare Devices: Evolution of MEMS and BioMEMS in the Era of the Internet of Bodies for Personalized Medicine. Micromachines (Basel). 16(10):1182, 2025. doi: 10.3390/mi16101182.
LIU C, FAN H, KIM M, ZHOU T, YANG P, ZHAO L, WANG Y, CHE Z, LIU CW, LI B, ZHU Y. Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare. Adv Sci (Weinh). e22900, 2026. doi: 10.1002/advs.202522900.
ZHAO Q, LI G, CAI J, ZHOU M, FENG L. A Tutorial on Internet of Behaviors: Concept, Architecture, Technology, Applications, and Challenges. IEEE Communications Surveys & Tutorials. 25(2):1227–1260, 2023. https://doi.org/10.1109/COMST.2023.3246993
CELIK A, SALAMA K N, ELTAWIL A M. The internet of bodies: A systematic survey on propagation characterization and channel modeling. IEEE Internet of Things Journal, v. 9, n. 1, p. 11-32, 2021. DOI: 10.1109/JIOT.2021.3093636
NADERALVOJOUD B, CURTIN C, ASCH SM, HUMPHREYS K, HERNANDEZ-BOUSSARD T. Evaluating the impact of data biases on algorithmic fairness and clinical utility of machine learning models for prolonged opioid use prediction. JAMIA Open. 8(5):ooaf115, 2025. doi: 10.1093/jamiaopen/ooaf115.
VAN DER VELDEN BHM, KUIJF HJ, GILHUIJS KGA, VIERGEVER MA. Explainable artificial intelligence (XAI) in deep learning-based medical image analysis. Med Image 79:102470, 2022. doi: 10.1016/j.media.2022.102470.
MOUSTATI I, GHERABI N. A novel hybrid XAI-RL framework for IoB-driven risk-adjusted portfolio optimization. ,Scientific African, 31, e03175, 2026. https://doi.org/10.1016/j.sciaf.2025.e03175.
FERETZAKIS G, VAGENA E, KALODANIS K, PERISTERA P, KALLES D, ANASTASIOU A. GDPR and Large Language Models: Technical and Legal Obstacles. Future Internet. 17(4):151, 2025. https://doi.org/10.3390/fi17040151
VILELA J, PEIXOTO M, SANTOS D E. Understanding regulatory compliance with LGPD: Empirical evidence from Brazilian organizations. Information and Software Technology, v. 182, p. 107645, 2026. DOI: 10.1016/j.infsof.2026.108090.
CORDEIRO, A. A. M.; SOBRAL, L. L. Desafios Regulatórios da Lei Geral de Proteção de Dados (LGPD) para Internet das Coisas (IoT). Revista Tecnologia, v. 45, n. 1, p. 1-15, 2024. DOI: 10.5020/23180730.2024.13998
KELLMEYER P, COCHRANE T, MÜLLER O, MITCHELL C, BALL T, FINS JJ, BILLER-ANDORNO N. The Effects of Closed-Loop Medical Devices on the Autonomy and Accountability of Persons and Systems. Camb Q Healthc Ethics. 25(4):623-33, 2016. doi: 10.1017/S0963180116000359. Erratum in: Camb Q Healthc Ethics. 26(1):180, 2017. doi: 10.1017/S0963180116000967.
MENNELLA C, MANISCALCO U, DE PIETRO G, ESPOSITO M. Ethical and regulatory challenges of AI technologies in healthcare. Heliyon. 10(4):e26297, 2024. DOI: 10.1016/j.heliyon.2024.e26297.
Mohammed s, Malhotra n. Ethical and regulatory challenges in machine learning-based healthcare systems: A review of implementation barriers and future directions. BenchCouncil Transactions on Benchmarks, Standards and Evaluations,5, Issue 1, 100215, 2025. DOI: 10.1016/j.tbench.2025.100215.
RUIZ-VANOYE J A, DÍAZ-PARRA O, MARROQUÍN-GUTIÉRREZ F, XICOTÉNCATL-PÉREZ J M, BARRERA-CÁMARA R A, FUENTES-PENNA A, SIMANCAS-ACEVEDO E, RODRÍGUEZ-FLORES J, MARTÍNEZ-MIRELES J R. Brain Data Security and Neurosecurity: Technological advances, Ethical dilemmas, and Philosophical perspectives. International Journal of Combinatorial Optimization Problems and Informatics, 15(5):17–35, 2024. https://doi.org/10.61467/2007.1558.2024.v15i5.555
CIRILLO F. Neurolaw, Neurorights and Neuroprivacy: Theoretical and Constitutional Issues. Midia Law. 2012-234, 2025.
IENCA, M. On Neurorights. Frontiers in Human Neuroscience, v. 15, p. 701258, 2021. DOI: 10.3389/fnhum.2021.701258
GUERRERO, F. Neurorights: A New Legal and Ethical Frontier. Journal of Medical Humanities and Ethics, v. 128, 2024. DOI: 10.1007/s12152-024-09568-z
BROWN, C.M.L. Neurorights, Mental Privacy, and Mind Reading. Neuroethics 17, 34, 2024. DOI: 10.1007/s12152-024-09568-z
Descargas
Publicado
Número
Sección
Licencia
Derechos de autor 2026 RSV

Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
